[Yui Asuna]

Here's my note: 4/10. (This used to be a 6, when I saw point 4)
And now, here's why:

1. WebRequest in the UI thread. Bad thing is bad. Multi-threading dude !
2. "https://twitter.com/search/realtime?q=" + bb + "&src=typd")" No. When you want to concat strings, you should use "&"
3. This code below V. First, it's alway better to use explicit variable name. Second, why aren't they declared as string ? (You can also reduct this in one line)

Code

Dim lol = Environment.GetFolderPath(Environment.SpecialFolder.Desktop)
Dim la As String = "\twitter.txt"
Dim aaa = lol + la

4. Just saw it when writing this line. Just NO. You don't use threading for webrequest, so what is the point of this ? VERY bad habit, and for nothing.

Code

Private Sub Form1_Load(sender As Object, e As EventArgs) Handles MyBase.Load
  CheckForIllegalCrossThreadCalls = False
    End Sub

5.

Code

Private Sub SWAG()

... Not a bad point in itself, just ... Explicit name, please, and not that !_!
[6.] Yeah, just one remark, no big deal:

Code

If CheckBox2.Checked = True Then

You can just write "if CheckBox2.Checked Then"

That's all. Be sure to correct these points in the future ;)
Didn't really looking in the RegEx and request in themself, I just saw some loose of time.
This post is not offensive. It's only meant to help.

[Yui Asuna]

Thanks for the feedback will have a look back on everything

No problem dude.
Oh thanks, someone that don't get mad when you correct them :)
Welcome to the .Net section dude !